Prof Ra'ed Abu Odeh

 

 

Prof Ra'ed Abu Odeh

Dr. Abu Odeh received his Ph.D. (1995) in Immunology and Molecular Biology from Idaho State University, Pocatello, ID, USA. Following that he did his post-doctoral training at UT Southwestern Medical Centre-Dallas. Subsequently, he worked as a senior research scientist and instructor at the University of Arizona college of Medicine in the Valley Fever Centre for Excellence-Tucson, AZ. Currently he is an Associate Professor in MLS department at the University of Sharjah. He also teaches Immunology and Molecular Genetics, among other courses. Dr. Abu Odeh’s research interests include immune responses in systemic fungi, vaccine studies (recombinant and DNA), transformation of systemic fungi, viral epidemiology and phylogenetics, and molecular immunology

Abstract

The vitamin D3-binding protein (Gc protein)-derived macrophage activating factor (GcMAF) activates macrophages against a variety of cancers. Deglycosylation of vitamin D binding protein by nagalase prevents its conversion to Gc-MAF, thus renders it ineffective. We investigated the effect(s) of GcMAF on microglial cells of the brain using BV-2 cell line. After 24-72 h stimulation with GcMAF, cells showed a significant change in morphology that was consistent with an increase in their metabolic activity and their level of connectivity. In another study we found that the levels of nagalase in cancer patients significantly dropped after administration of Gc-MAF..